Resveratrol – Resveratrol stimulates AMPK and sirtuins, inhibits mTOR, and promotes the production of new, healthy mitochondria. It also increases NAD+, an essential cofactor for sirtuin activation.

Berberine – Berberine is a bitter phytochemical that protects the liver against excessive fat accumulation. It also activates AMPK and inhibits mTOR, improving glucose and lipid metabolism.

Quercetin – Quercetin is an AMPK-activating polyphenol that also acts as a senolytic, a compound that selectively induces the death of senescent cells, or cells that have ceased to be functional and instead secrete pro-inflammatory molecules that harm healthy cells around them. Quercetin’s senolytic activity may stem the tide of aging and promote a youthful physiology.

Milk Thistle – Milk Thistle is well-known for its liver-protective properties. It’s main constituent, silymarin, also inhibits mTOR, allowing AMPK to perform its vital roles in the body.

Diindolylmethane (DIM) – DIM increases the expression of autophagy-associated genes through AMPK activation. It is also immune-modulating, shifting the balance towards calming T-regulatory cells.

Use Alone or With Fasting – This formula complements intermittent fasting and keto or carb-restricted diets (and may allow for more flexible fasting protocols).