EPO-Evening Primrose Oil provides gamma-linolenic acid (GLA), an essential fatty acid that supports hormonal balance, healthy cytokine responses, skin integrity, and eye comfort.* GLA contributes to cell membrane health and prostaglandin production, helping to maintain menstrual comfort, menopausal symptom relief, skin hydration, and tear production.* Each softgel contains 45 mg of GLA from 500 mg of evening primrose oil.

Ingredients

Serving Size: 1 softgel
Servings Per Container: 120

Amount per serving:

Calories: 5
Calories from Fat: 5
Total Fat: 500 mg
Evening Primrose Oil: 500 mg
Gamma-Linolenic Acid (ω-6): 45 mg
Linoleic Acid (ω-6): 365 mg
Oleic Acid: 35 mg

Other Ingredients

Gelatin, glycerin, water.

Suggested Use

As a dietary supplement, take 1 softgel daily with meals, or as directed by a healthcare practitioner.

If you are pregnant or lactating, have any health condition or are taking any medication, consult your healthcare practitioner before use.

Store in a cool, dry place, tightly capped, away from light. Keep out of the reach of children. Use only if safety seal is intact. Variations in product color may occur.

How It Works

• Gamma-Linolenic Acid (GLA): A key fatty acid in evening primrose oil that supports cell membrane structure and is a precursor to prostaglandin E1 (PGE1), which helps balance cytokines and hormonal signaling.*[1-3]
• Hormonal Health: Clinical studies show that daily supplementation with 1,000 mg EPO twice daily (delivering ~180 mg GLA) for 4–8 weeks supports mood, energy, and vasomotor symptoms in menopausal women.*[4-6]
• PMS and Breast Discomfort: EPO in doses of 1.5–3 grams daily has been studied for its ability to support common premenstrual symptoms, potentially through its modulation of prolactin activity and prostaglandin signaling.*[3]
• Skin Barrier Function: GLA supports skin hydration and barrier integrity by influencing lipid composition and prostaglandin production, with measurable improvements seen in moisture retention and skin smoothness.*[7-9]
• Eye Comfort: In contact lens wearers, 300 mg of GLA from EPO over six months supported tear production and comfort compared to placebo, likely through effects on ocular surface cytokine balance and barrier function.*[10-12]

Who It's For

EPO is ideal for women seeking support for menstrual or menopausal symptoms, and for individuals interested in promoting healthy skin and eye hydration.*

Special Features

Each softgel provides a standardized dose of 45 mg GLA from 500 mg evening primrose oil, offering flexibility for personalized dosing from foundational to clinically studied ranges. Cold-pressed and non-GMO.*

References

1. Fan YY, Chapkin RS. J Nutr. 1998;128(9):1411–4.
2. Fang W, et al. Can J Physiol Pharmacol. 2010;88(5):576–83.
3. Kapoor R, Huang YS. Curr Pharm Biotechnol. 2006;7:531–4.
4. Gandhi AB, Desai A. J Indian Med Assoc. 2022;120(7):75–9.
5. Kazemi F, et al. J Menopausal Med. 2021;27(1):8–14.
6. Safdari F, et al. J Menopausal Med. 2021;27(2):58–65.
7. Muggli R. Int J Cosmet Sci. 2005;27(4):243–9.
8. Senapati S, et al. Indian J Dermatol Venereol Leprol. 2008;74(5):447–52.
9. Chung BY, et al. Ann Dermatol. 2018;30(4):409–16.
10. Simon D, et al. Adv Ther. 2014;31(2):180–8.
11. Kokke KH, et al. Cont Lens Anterior Eye. 2008;31(3):141–70.
12. Barabino S, et al. Cornea. 2003;22(2):97–101.

Additional Information

Supports hormonal balance, skin hydration, and eye comfort with GLA from Evening Primrose Oil*

Health products and supplements are an affordable and effective way to ensure you and your loved ones are getting the daily recommended intake of essential vitamins, minerals and other important nutrients necessary for optimal health.

EPO

Ingredients

Suggested Use

How It Works

Who It's For

Special Features

References

Additional Information

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