

Health products and supplements are an affordable and effective way to ensure you and your loved ones are getting the daily recommended intake of essential vitamins, minerals and other important nutrients necessary for optimal health.
Serving Size: 1 capsule
Servings Per Container: 90
Amount per serving:
Riboflavin (as Riboflavin-5-Phosphate): 10 mg
Vitamin B6 (50% as Pyridoxine HCl and 50% as Pyridoxal-5-Phosphate): 30 mg
Folate (as 400 mcg of 5-Methyltetrahydrofolate [from 740 mcg [6S]-5-methyltetrahydrofolate acid, glucosamine salt]): 667 mcg DFE
Vitamin B12 (as Methylcobalamin): 400 mcg
Zinc (Zinc Picolinate): 5 mg
Trimethylglycine: 500 mg
L-Serine: 100 mg
L-Glutathione (reduced): 50 mg
Other Ingredients
Hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, silicon dioxide.
As a dietary supplement, take 1 capsule daily with meals, or as directed by a healthcare practitioner.
If you are pregnant or lactating, have any health condition or are taking any medication, consult your healthcare practitioner before use.
Store in a cool, dry place, tightly capped, away from light. Keep out of the reach of children. Use only if safety seal is intact. Variations in product color may occur.
• L-methylfolate supplies activated folate to support the methionine cycle, bypassing MTHFR polymorphisms.*[3-4]
• Methylcobalamin is the bioactive form of vitamin B12, directly participating in methylation reactions required for homocysteine metabolism.*
• Trimethylglycine (betaine) supports homocysteine-to-methionine conversion via the BHMT pathway, a folate-independent route active in the liver and kidneys.*
• Serine contributes methyl groups for folate regeneration and promotes cysteine and taurine production for downstream antioxidant support.*[6]
• Zinc is a cofactor for both methionine synthase and BHMT enzymes that catalyze the remethylation of homocysteine.*[1]
• Vitamin B6 supports both the folate and transsulfuration pathways, supporting cysteine and glutathione synthesis.*[5]
• Riboflavin (vitamin B2) is a required cofactor for MTHFR and may enhance folate utilization in individuals with the 677TT genotype.*[3]
• Glutathione helps balance oxidative stress that may deplete methylation capacity by competing with SAMe synthesis for cysteine.*[7][2]
• The homocysteine to methionine cycle contributes to the formation of SAMe (S-adenosylmethionine) SAM-e which is central to creatine, neurotransmitter, and DNA methylation pathways.*[2]
Recommended for individuals looking to support healthy methylation, cardiovascular function, or antioxidant balance.*
Combines active methyl donors, essential enzyme cofactors, and antioxidant support into a formula designed for comprehensive homocysteine and one-carbon metabolism support.*
1. Jing M et al. J Trace Elem Med Biol. 2015;30:77–82.
2. Bottiglieri T. Am J Clin Nutr. 2002;76(5):1151S–7S.
3. McNulty H et al. Circulation. 2006;113(1):74–80.
4. McNulty H et al. Curr Dev Nutr. 2020;4(1):nzz102.
5. Ubbink JB et al. J Clin Invest. 1996;98(1):177–84.
6. Kalhan S, Hanson R. J Biol Chem. 2012;287(24):19786–91.
7. Wang L et al. Exp Ther Med. 2020;20(2):938–44.
Methylation Support for Homocysteine and Cellular Health*
Our mission is to help you enjoy optimum health through proper nutrition! Good health is all about looking your best and having the energy and stamina to do the things you love. It's difficult to be productive and happy if you're sick or run down all the time. We believe strongly that certain supplements should be at the core of your health program.
We are committed to providing only high quality products. Many brands will never be sold in our stores due to concerns we have with their quality control or business practices.
BioHelp is a family owned and operated nutraceutical distribution company. BioHelp offers a wide range of professional only product lines, to everyone who's main goal is to achieve a better quality of life, and we take pride in our ability to educate our clients on product selection. We are your personal concierge to the nutraceutical world. With the growing awareness of food allergies, our staff is able to provide support on products that would best suit the best. Make sure your body is getting all the nutrition it needs to stay healthy and keep you strong. BioHelp will steer you in the right direction and ensure your supplements fit your goals and lifestyle.
Registered to Echidna LLC, TIN 460522441
1600 148th Avenue Southeast,
Bellevue, WA 98007