L-Ornithine-L-Aspartate (LOLA) supports healthy nitrogen metabolism by promoting the natural detoxification of ammonia through the urea cycle and glutamine synthesis pathways.* By providing key amino acids, LOLA helps maintain liver function, ammonia clearance, and metabolic balance, especially during times of increased nitrogen stress.* Each serving delivers 3 grams of clinically relevant LOLA in a versatile powdered form.*

Ingredients

Serving Size: 1 rounded teaspoon
Servings Per Container: approx. 33

Amount per serving:

L-Ornithine-L-Aspartate: 3 g

Other Ingredients

Suggested Use

As a dietary supplement, take 1 rounded teaspoon three times daily, or as directed by a healthcare practitioner.

If you are pregnant or lactating, have any health condition or are taking any medication, consult your healthcare practitioner before use.

Store in a cool, dry place, tightly capped, away from light. Keep out of the reach of children. Use only if safety seal is intact. Variations in product color may occur.

How It Works

• L-Ornithine activates carbamoyl phosphate synthetase, the rate-limiting enzyme of the urea cycle, enhancing the conversion of ammonia to urea in periportal hepatocytes for excretion.*[1]
• L-Aspartate serves as a substrate in transamination reactions and contributes to glutamine synthesis, aiding in ammonia removal via non-urea pathways.*[3]
• Glutamine Synthetase Activation in perivenous hepatocytes, skeletal muscle, and brain tissue facilitates an additional mechanism for reducing circulating ammonia.*[3]
• Clinical Research supports the use of oral LOLA in improving ammonia metabolism and mental state, especially in individuals with hepatic metabolic burden.*[4]
• Meta-Analysis Findings indicate that LOLA supplementation significantly supports detoxification pathways.*[4,5]

Who It's For

Designed for individuals seeking targeted support for ammonia clearance and liver-related nitrogen metabolism, or those seeking to ease metabolic stress, support a high protein diet, or support detoxification.*

Special Features

Each serving delivers 3 grams of high-quality LOLA in an easy-to-use powdered format, allowing flexible dosing and alignment with clinical trial protocols.*

References

1. Weiner ID, et al. Clin J Am Soc Nephrol. 2015;10(8):1444–1458.
2. Butterworth RF. Metab Brain Dis. 2020;35(1):75–81.
3. Butterworth RF. Drugs R D. 2021;21(2):123–132.
4. Butterworth RF, Canbay A. Dig Dis. 2019;37(1):63–68.

Additional Information

Promotes Healthy Ammonia Clearance and Liver-Supportive Nitrogen Metabolism*

Health products and supplements are an affordable and effective way to ensure you and your loved ones are getting the daily recommended intake of essential vitamins, minerals and other important nutrients necessary for optimal health.

L-Ornithine-L-Aspartate

Ingredients

Suggested Use

How It Works

Who It's For

Special Features

References

Additional Information

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