

Health products and supplements are an affordable and effective way to ensure you and your loved ones are getting the daily recommended intake of essential vitamins, minerals and other important nutrients necessary for optimal health.
Thyroid Zen Defense is designed to support three key pathways for maintaining healthy thyroid and immune function.* This advanced formula features Holixer® Holy basil extract, clinically studied for its ability to promote cortisol balance and a healthy stress response, both of which are vital for maintaining thyroid health.* A combination of selenium and myo-inositol, included in a clinically-supported ratio, work together to promote thyroid hormone production, cellular function, and overall endocrine balance.* Time-honored shiitake mushroom extract is included to enhance immune resilience and help maintain healthy immune function by supporting natural killer (NK) cell activity and immunomodulation. With its blend of clinically supported and traditional ingredients, Thyroid Zen Defense offers a multi-mechanistic approach to maintaining optimal thyroid, mood, and immune health.
Serving Size: 2 capsules
Servings Per Container: 60
Amount per serving:
Selenium (as L-selenomethionine): 83 mcg
Myo-Inositol: 600 mg
Holy Basil Extract (as Holixer™ Ocimum sanctum leaf extract, standardized to > 5% Ocimum Bioactive Complex): 125 mg
Shiitake Extract 4:1 (Lentinula edodes, fruiting body): 500 mg
Other Ingredients
Hydroxypropyl methylcellulose, microcrystalline cellulose, magnesium stearate, silicon dioxide.
As a dietary supplement, take 2 capsules twice daily, or as directed by a healthcare practitioner.
If you are pregnant or lactating, have any health conditions or are taking any medication, consult your healthcare practitioner before use.
Store in a cool, dry place, tightly capped, away from light. Keep out of the reach of children. Use only if safety seal is intact. Variations in product color may occur.
• Holy Basil (Holixer® extract): Clinically shown to reduce perceived stress and support cortisol balance, this adaptogen helps buffer stress-related disruptions to the HPT axis.*[1]
• Myo-Inositol + Selenium: In combination, this duo has been shown in multiple trials to support thyroid hormone biosynthesis and regulation more effectively than selenium alone.*[2–5]
• Myo-Inositol: Supports iodine uptake and organification, essential for thyroid hormone production in thyrocytes.*[4]
• Selenium: A cofactor for deiodinase and antioxidant enzymes (glutathione peroxidases, thioredoxin reductases), selenium protects thyroid tissue from oxidative stress and modulates immune signaling.*[5–7]
• Shiitake Mushroom (Lentinula edodes): Provides immunomodulatory beta-glucans and polysaccharides that influence natural killer (NK) cell activity, supporting immune surveillance and thyroid-immune interaction.*[8,9]
• Immune-Thyroid Interactions: NK cell activity plays a regulatory role in thyroid function, particularly during aging and times of immune activation.*[10]
Designed for individuals seeking stress resilience and thyroid balance, particularly those seeking optimal thyroid health, stress response balance, or immune-thyroid axis support.*
Provides a cohesive formula aimed at the triad of stress, thyroid, and immune health.*
1. Lopresti AL, et al. Front Nutr. 2022;9:965130. doi:10.3389/fnut.2022.965130
2. Ferrari SM, et al. Eur Rev Med Pharmacol Sci. 2017;21(2 Suppl):36–42.
3. Pace C, et al. Endocr J. 2020;67(11):1093–1098.
4. Paparo SR, et al. Front Endocrinol (Lausanne). 2022;13:930756. doi:10.3389/fendo.2022.930756
5. Nordio M, Basciani S. Eur Rev Med Pharmacol Sci. 2017;21(2 Suppl):51–59.
6. Wang F, et al. Front Endocrinol (Lausanne). 2023;14:1133000. doi:10.3389/fendo.2023.1133000
7. Pirola I, et al. Endocrinol Diabetes Nutr (Engl Ed). 2020;67(1):28–35.
8. Bisen PS, et al. Curr Med Chem. 2010;17(22):2419–2430.
9. Roszczyk A, et al. Int J Mol Sci. 2022;23(16):8980. doi:10.3390/ijms23168980
10. Lee EK, Sunwoo JB. Endocrinol Metab (Seoul). 2019;34(2):132–137
Targeted Thyroid and Stress Response Support with Adaptogens and Immune-Modulating Nutrients*
Our mission is to help you enjoy optimum health through proper nutrition! Good health is all about looking your best and having the energy and stamina to do the things you love. It's difficult to be productive and happy if you're sick or run down all the time. We believe strongly that certain supplements should be at the core of your health program.
We are committed to providing only high quality products. Many brands will never be sold in our stores due to concerns we have with their quality control or business practices.
BioHelp is a family owned and operated nutraceutical distribution company. BioHelp offers a wide range of professional only product lines, to everyone who's main goal is to achieve a better quality of life, and we take pride in our ability to educate our clients on product selection. We are your personal concierge to the nutraceutical world. With the growing awareness of food allergies, our staff is able to provide support on products that would best suit the best. Make sure your body is getting all the nutrition it needs to stay healthy and keep you strong. BioHelp will steer you in the right direction and ensure your supplements fit your goals and lifestyle.
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1600 148th Avenue Southeast,
Bellevue, WA 98007