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Integrative Therapeutics Curalieve provides advanced absorption curcumin due to its amorphous structure and excipient profile, which contributes to enhanced dispersibility and bioavailability. Curcumin has been studied and evaluated for its role in supporting antioxidant pathways and its effects on the body.* 1,2 Curalieve’s key ingredient is curcuRouge®, an amorphous solid dispersion of curcumin.
In humans, curcumin is very poorly absorbed. Curalieve is formulated with curcuRouge®, an amorphous solid dispersion containing curcumin extract. Native curcumin has a propensity to form a crystalline structure that repels water. This crystalline structure is why consumption of native curcumin, even in gram amounts, yields little change in blood curcumin levels. 3
The technology used to develop curcuRouge overcomes these challenges by first melting curcumin to reduce the crystalline structure, then rapidly dispersing the curcumin with food-based polymers. curcuRouge has a smaller particle size and improved dispersibility compared to native curcumin. The amorphous nature of curcuRouge contributes to its enhanced dispersibility, higher bioavailability as shown in both animal and human research. 4
In a single-dose, double-blind, two-way crossover study, curcuRouge exhibited a higher bioavailability compared to submicron-particle colloidal dispersion. 5
curcuRouge was over 3 times more bioavailable than submicron-particle colloidal dispersion. The maximal concentration (Cmax) of curcumin reached in the blood was over 5 times greater with curcuRouge compared to submicron-particle colloidal dispersion. curcuRouge was absorbed significantly faster than submicron-particle colloidal dispersion.
curcuRouge was over 3 times more bioavailable than submicron-particle colloidal dispersion.
The maximal concentration (Cmax) of curcumin reached in the blood was over 5 times greater with curcuRouge compared to submicron-particle colloidal dispersion.
curcuRouge was absorbed significantly faster than submicron-particle colloidal dispersion.
REFERENCES
Li H, Sureda A, Devkota HP, et al. Biotechnol Adv. 2020;38:107343. doi:10.1016/j.biotechadv.2019.01.010
Gautam SC, Gao X, Dulchavsky S. Adv Exp Med Biol. 2007;595:321-341. doi:10.1007/978-0-387-46401-5_14
Lao, C. D., Ruffin, M. T., 4th, Normolle, D., Heath, D. D., Murray, S. I., Bailey, J. M., Boggs, M. E., Crowell, J., Rock, C. L., & Brenner, D. E. (2006). BMC complementary and alternative medicine, 6, 10. https://doi.org/10.1186/1472-6882-6-10
Wegiel, LA et al., Pharmaceutical Development and Technology, 2014; 18(8): 976-986. DOI: 10.3109/10837450.2013.846374
Yoichi Sunagawa, Yusuke Miyazaki, et al. Journal of Functional Foods, Volume 81, 2021, 104443, ISSN 1756-4646, https://doi.org/10.1016/j.jff.2021.104443\
| Serving Size: 2 capsule | Amount / Serving | %DV |
|---|---|---|
| Total Carbohydrate | <1g | <1%† |
| curcuRouge® enhanced bioavailable, amorphous curcumin extract from Curcuma longa rhizome | 450mg | ** |
| Serving Size: 2 capsules | Amount / Serving | %DV |
| Total Carbohydrate | <1g | <1%† |
| curcuRouge® enhanced bioavailble, amorphous curcumin extract from Curcuma longa rhizome | 450mg | ** |
** Daily Value (DV) not established †Percent daily value is based on a 2000 calorie diet
Other Ingredients cellulose, plant-derived capsule (hypromellose), food starch-modified, calcium stearate, silica
Does Not Contain: Wheat Gluten Soy Dairy Artificial Flavors
Curalieve Directions and/or Dosage Adults take 2 capsules daily. Do not exceed recommended dose. Warning Do not take if you are pregnant or nursing. If you have gallstones, a bile duct obstruction, or if you are taking any medications, consult a healthcare professional before use. Keep out of reach of children. Safety sealed with inner seal. Do not use if seal is broken or missing. Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.
Curalieve Directions and/or Dosage Adults take 2 capsules daily. Do not exceed recommended dose. Warning Do not take if you are pregnant or nursing. If you have gallstones, a bile duct obstruction, or if are taking any medications, consult a healthcare professional before use. Keep out of reach of children. Safety sealed with inner seal. Do not use if seal is broken or missing. Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.
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BioHelp is a family owned and operated nutraceutical distribution company. BioHelp offers a wide range of professional only product lines, to everyone who's main goal is to achieve a better quality of life, and we take pride in our ability to educate our clients on product selection. We are your personal concierge to the nutraceutical world. With the growing awareness of food allergies, our staff is able to provide support on products that would best suit the best. Make sure your body is getting all the nutrition it needs to stay healthy and keep you strong. BioHelp will steer you in the right direction and ensure your supplements fit your goals and lifestyle.
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